Amsterdam UMC, The Netherlands
Victor Gerdes qualified as an internist in 2003 and started at the department of Vascular Medicine of the Academic Medical Centre and the Slotervaart hospital, both in Amsterdam. He has always combined his clinical work with a wide scope as a general internist with research on cardiovascular disease and obesity. In 2006 he left the Academic Medical Centre and established with surgeons of the Slotervaart hospital a centre for obesity surgery which is at present one of the leading bariatric centres in the Netherlands. From the beginning, this centre has designed and performed clinical studies. Together with investigators from Copenhagen, Gothenborg, Amsterdam and Groningen he has set up the Baria study, a large study on systems biology and gut microbiota to understand the metabolic effects of bariatric surgery, funded by the Novo Nordisk Foundation. After closure of the Slotervaart hospital end of 2018 he and his team continued the clinical work and research projects at the Spaarne Gasthuis, Hoofddorp, and Amsterdam UMC, Amsterdam.
There is growing evidence that the gut microbiome is involved in obesity, type 2 diabetes and cardiovascular disease. The introduction of new sequencing technologies has enabled investigators to evaluate microbiome compostion in patients and healthy persons and to perform studies to gather insight in the function of the microbiome and its metabolites. Alterations of the gut microbiome and metabolites have been observed repeatedly in patients with type 2 diabetes and cardiovascular disease. Fecal transplantation studies have shown clear influences, especially in mice. In humans however, causality has not been proven yet. At present, a number of studies is being performed to elucidate this.