Professor, Ph.D., Department of Nutrition, Exercise and Sports, SCIENCE, University of Copenhagen, Denmark
Anne Raben (AR) has a Ph.D. in Human Nutrition, and Professor in the Obesity Research Unit and Head of Study Board at the Department of Nutrition, Exercise and Sports (NEXS), SCIENCE, University of Copenhagen, Denmark. AR has solid experience with clinical intervention studies within obesity and related diseases. Main research topics have been on dietary and drug-induced changes in body weight, appetite regulation, energy expenditure, metabolic parameters and risk markers of CVD and T2D. Especially, the role of different macronutrients and carbohydrates – including sugar, non-caloric sweeteners, and glycemic index - has been in focus. Recently, AR was Project Coordinator of a large multinational EU FP7 project “PREVIEW”, Prevention of Diabetes through lifestyle Intervention and populations studies in Europe and around the World (www.previewstudy.com, 2013–18). Currently, AR is co-coordinator of a new Horizon-2020 project “SWEET” focusing on (www.sweetproject.eu, 2018–2023) the impact of sweeteners and sweeteners enhancers on health, obesity, safety and sustainability. “
There is no evidence that the amount of dietary protein, glycaemic index, or intensity of physical activity are important for prevention of type-2 diabetes (T2D). We aimed to compare the impact of two diets: High-protein (HP), low-glycaemic index (GI) and Moderate-protein (MP), moderate-GI, combined with high-intensity (HI) physical activity (PA) or moderate-intensity (MI) PA on incidence of T2D.
The PREVIEW lifestyle intervention study (www.previewstudy.com) is to date the largest of its kind. The main hypothesis was that a high-protein (HP), low-glycaemic index (GI) diet would be superior to a moderate-protein (MP), higher-GI diet (as used in current practice) for the prevention of type-2 diabetes (T2D). Further, it was hypothesized that high-intensity (HI) physical activity (PA) would be superior to moderate-intensity (MI) PA.
A 3-year multicentre randomised trial was conducted in 8 countries using a 2x2 diet-by-PA factorial design. A total of 2,326 adults (25-70 y, BMI ≥ 25 kg/m2) with pre-diabetes were enrolled. An 8-week weight-reduction phase was followed by a 3 year randomised weight-maintenance phase. The primary endpoint was incidence of T2D analysed by diet treatment (Clinicaltrials.gov # NCT01777893; Fogelholm et al 2017; Christensen et al 2018). Results from the 3 year multinational, randomised trial will be shown.
References: Christense et al; DOM 2018. Fogelholm et al Nutrients 2017. Funding: EU FP7 grant # 312057. The Cambridge Weight Plan©. NHMRC - EU Collaborative Grant, AU. GI Foundation Australia. NZ HRC (14/191), Univ of Auckland Faculty Research Development Fund, NZ. Registration: Clinicaltrials.gov: NCT01777893.