Professor of Gastroenterology, University of Gothenburg, and Senior Consultant, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Adjunct Professor of Medicine, University of North Carolina (UNC) School of Medicine, Chapel Hill, NC, USA.
Doctor Magnus Simrén graduated from medical school, University of Gothenburg in 1991, and afterwards completed his internship and fellowship in internal medicine at the County Hospital of Lidköping. From 1998 to 1999, Doctor Simrén completed his fellowship in gastroenterology at Sahlgrenska University Hospital, and has been working as a specialist physician in gastroenterology at Sahlgrenska University Hospital since 1999. He was a post-doctoral research fellow at the University of Leuven, Belgium, in 2002. He was visiting research scientist at the Center for Functional GI and Motility Disorders, University of North Carolina (UNC), Chapel Hill, NC, United States 2015-2016, and currently holds a position as Adjunct professor of Medicine at UNC School of Medicine (2017-). Since 2013 he has a combined position as Professor of Gastroenterology at the University of Gothenburg, and Senior Consultant at the Sahlgrenska University Hospital in Gothenburg, Sweden. Doctor Simrén’s main research areas are the pathogenesis and pathophysiology of functional GI disorders, as well as the treatment of these. He has published more than 280 original articles and written several book chapters on GI motility diseases and functional GI disorders, and is currently supervisor for eighteen PhD students and three post-docs. Doctor Simrén is a council/board member in several international organizations, e.g. United European Gastroenterology (UEG) and the Rome Foundation Scientific Committee 2013-2017, and is currently the UEG Secretary General (2018-2021). Professor Simrén has also been working as Deputy Editor and Associate Editor of Gut, and as the Clinical Editor of Neurogastroenterology and Motility.
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders. A stepwise management approach is advocated for patients with IBS. For a substantial proportion of patients with mild symptoms, general management principles, including making a confident diagnosis and offering explanation, reassurance, and dietary and lifestyle advice, are sufficient. However, many patients continue to have moderate-to-severe symptoms and are not satisfied solely with this approach. In these patients, use of more advanced dietary interventions or pharmacotherapy on the basis of the predominant symptom (constipation, diarrhoea, pain, or bloating) or combination of symptoms is the next step. For patients with symptoms that are refractory to these initial treatment options and those who have comorbid conditions or psychological symptoms, a combination of therapies should be used, and the use of psychotropic drugs and psychological treatment alternatives is often effective.